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M9550101.TXT
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1995-03-04
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Document 0101
DOCN M9550101
TI Cognitive event-related potentials and brain magnetic resonance imaging
in HTLV-1 associated myelopathy (HAM).
DT 9505
AU Fukushima T; Ikeda T; Uyama E; Uchino M; Okabe H; Ando M; First
Department of Internal Medicine, Kumamoto University School; of
Medicine, Japan.
SO J Neurol Sci. 1994 Oct;126(1):30-9. Unique Identifier : AIDSLINE
MED/95138729
AB Auditory and visual cognitive event-related potentials (ERPs) were
investigated in 14 patients with HTLV-1 associated myelopathy (HAM) and
in 36 normal controls. In the HAM patients, the latencies of P300 and
N200 by the auditory tone method were significantly delayed, and N100 by
the auditory click method was significantly delayed in latency. No
abnormal ERP components were observed with visual methods. While these
auditory abnormal ERPs were present in the HAM patients, there was no
evidence of visual abnormal ERPs. Abnormal lesions on the white matter
were evident at magnetic resonance imaging (MRI) in 6 (75%) of 8
patients. There was no correlation between MRI lesions and the
abnormalities of ERPs, but there was a significant correlation between
bifrontal index on MRI and P300 amplitudes at Cz and Pz sites by
auditory tone method. In one patient, atrophy of bilateral parietal
lobes was seen on MRI and P300 latencies delayed using various methods.
Therefore, the possibility that electrophysiological cognitive
impairment in patients with HAM is related to brain atrophy rather than
to white matter lesions requires attention.
DE Adult Aged Alcoholism/COMPLICATIONS Atrophy Autoimmune
Diseases/COMPLICATIONS Brain/*PATHOLOGY Cognition/*PHYSIOLOGY
Cognition Disorders/*ETIOLOGY Drugs *Evoked Potentials, Auditory
Evoked Potentials, Auditory, Brain Stem *Evoked Potentials, Visual
Female Human *Magnetic Resonance Imaging Male Middle Age
Paraparesis, Tropical Spastic/COMPLICATIONS/*PHYSIOPATHOLOGY/
PSYCHOLOGY Reaction Time JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).